the lack of authentic standards has limited the quantitative analysis of herbal drugs in biological samples. the present work demonstrated a practicable strategy for the assay of herbs and their metabolites independent of authentic standards. a liquid chromatography–electrospray ionization–mass spectrometry (lc–esi–ms) method for the qualitative and quantitative determination of the metabolites...

Citation: Petras D, Koester I, Da Silva R, Stephens BM, Haas AF, Nelson CE, Kelly LW, Aluwihare LI and Dorrestein PC (2017) High-Resolution Liquid Chromatography Tandem Mass Spectrometry Enables Large Scale Molecular Characterization of Dissolved Organic Matter. Front. Mar. Sci. 4:405. doi: 10.3389/fmars.2017.00405 High-Resolution Liquid Chromatography Tandem Mass Spectrometry Enables Large Sca...

in previous studies, mebudipine, a dihydropyridine calcium channel blocker, showed a considerable potential to be used in cardiovascular diseases. the aim of the current study was to develop a valid method using reversed-phase high performance liquid chromatography coupled with electrospray ionization mass spectrometry to assay mebudipine in the human plasma. separation was achieved on a zorbax...

1. Armstrong VW, Oellerich M. New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine. Clin Biochem 2001;34:9–16. 2. Kahan BD, Keown P, Levy GA, Johnston A. Therapeutic drug monitoring of immunosuppressant drugs in clinical practice. Clin Ther 2002;24:330–50. 3. Oellerich M, Armstrong VW. Two-hour cyclosporine concentration determination: an appro...

background ziziphora tenuior l. known as kakuti in persian, is used in traditional medicine for fever, dysentery, uterus infection and as an analgesic. it is used also in the treatment of gastrointestinal disorders as carminative, or remedy of diarrhea or nausea. major components of plant essential oil including pulegone, isomenthone, thymol, menthone, and piperitone are suggested to be respons...

Submit Manuscript | http://medcraveonline.com Abbreviations: BAM: Bile Acid Malabsorption; CA: Cholic Acid; CDCA: Chenodeoxycholic Acid; DCA: Deoxycholic Acid; ASBT: Apical Sodium-dependent Bile Acid Transporter; IBS-D: Diarrhea-Predominant Irritable Bowel Syndrome; SeHCAT: Selenium HomotauroCholic Acid Test, FGF: Fibroblast growth factor; GPBAR1: G Protein-coupled Bile Acid Receptor 1; CYP7A1:...

The Mario Negri Institute has largely contributed in its many years to the development of pharmacokinetics, introducing new analytical techniques such as gas and liquid chromatography combined or not with mass spectrometry.(Sottani C, et al. Structural characterization of monoand dihydroxylated metabolites of paclitaxel in rat bile using liquid chromatography/ion spray tandem mass spectrometry....

Citation: Zhang X, Li J, Xie B, Wu B, Lei S, Yao Y, He M, Ouyang H, Feng Y, Xu W and Yang S (2018) Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Mucilage-Induced Rat Model Using Liquid Chromatography Tandem Mass Spectrometry. Front. Pharmacol. 9:282. doi: 10.3389/fphar.2018.00282 Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Muci...